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Polynucleotide treatment, commonly known as “salmon sperm,” is a cutting-edge innovation in regenerative aesthetic medicine. Its goal is to restore the skin’s vitality by stimulating its natural repair and hydration mechanisms.
Polynucleotides (PN) are highly purified DNA fragments extracted from salmon sperm due to its exceptional biocompatibility with human skin.These biologically active molecules promote cellular regeneration, stimulate collagen and elastin production, improve microcirculation, and help rebuild dermal structure.Their anti-inflammatory and antioxidant effects contribute to repairing damaged tissue and restoring a healthy, glowing complexion.

This treatment is suitable for anyone looking to improve their skin’s quality and texture. It is particularly recommended for:
The treatment consists of intradermal micro-injections performed with very fine needles in the targeted areas. A session lasts about 20 to 30 minutes and is performed without anesthesia (or with a topical numbing cream for enhanced comfort). The injections are precise, light, and very well tolerated, with no significant discomfort afterward.
For optimal results, an initial protocol of 3 to 4 sessions spaced 2 to 3 weeks apart is recommended. A maintenance session may be considered every 4 to 6 months depending on the skin’s needs.

After-effects are minimal: small redness or papules may appear right after treatment, but they typically disappear within a few hours. It is recommended to avoid makeup, sauna, and sun exposure for 24 hours. No social downtime is required—normal activities can be resumed immediately.
Visible improvement usually begins after the second session:
The skin appears more hydrated, softer, and more radiant.
Over the following weeks, the texture refines, the complexion becomes more even, and skin firmness improves significantly.
The final result is rejuvenated, glowing skin that looks naturally refreshed.
Polynucleotides are gaining global attention because they don’t just hydrate the skin—they actively repair it. By improving cellular function, reducing inflammation, and boosting collagen production, they offer natural, long-lasting rejuvenation without changing facial volume. This makes them ideal for patients who want visible improvement while maintaining a completely natural look.

If you’re looking to enhance your skin’s quality rather than alter your appearance, polynucleotides are an excellent choice. They’re ideal for anyone experiencing dullness, early aging, loss of firmness, or delicate under-eye concerns. Because the treatment strengthens the skin from within, it suits all skin types and is especially beneficial for those seeking natural, regenerative results with minimal downtime. A consultation allows your practitioner to assess your needs and create a personalized treatment plan for the best outcome.
What is the difference between polynucleotides and hyaluronic acid?
Hyaluronic acid hydrates and restores volume, while polynucleotides stimulate cellular regeneration and natural collagen production. They do not add volume but improve deep skin quality and firmness.
Can polynucleotides be combined with other treatments?
Yes. They pair very well with PRF, microneedling, skinboosters, or rejuvenation lasers to enhance cellular stimulation and improve skin texture.
Is the treatment painful?
No. The injections are superficial and well tolerated. A numbing cream can be applied beforehand for added comfort.
When are the first results visible?
Improvements generally appear after the second session, with optimal results after 3 to 4 sessions.
Is the treatment safe?
Yes. Polynucleotides are highly purified, biocompatible, and fully resorbable. There are no known allergic risks, and the treatment is suitable even for sensitive skin.
Your skin deserves true regeneration, not just surface improvement. Discover how Polynucleotides can restore hydration, firmness, and radiance by repairing your skin at the cellular level. Schedule your confidential consultation at Guess Clinic, Boulevard de la Grande Ceinture, Ain Diab, Casablanca by calling +212 522 79 79 11. Take the first step toward healthier, revitalized, naturally glowing skin.